Key words
Objectives
It doesn't strike so directly, but a lot of organic molecules possess
different three-dimensional forms. Some of them switch fast between each
other, some others are stable in time. In nature often only one or a limited
number of these are known. The use by the industry of this limited number of
forms in pharmaceuticals or in the protection of plants is more efficient
and has a smaller effect on the environment. It's why students who follow a
chemically based education (chemistry, biochemistry, textile, agriculture,..) must have a thoroughly understanding of the three-dimensional
structure of organic compounds.
In a second part the mechanisms of organic reactions are studied in a more
detailed form. The students must have insight in the principles associated
with the conversions of the different chemical functional groups, so they
should be able to handle problems in the organic synthesis by logical
reflection.
Prerequisites
The students must have a sufficient knowledge of basic organic chemistry.
Topics
Part 1: theoretical session
Stereochemistry: conformational analysis en stereoisomerism; applications in
some specific domains of the organic chemistry and biochemistry.
Reactivity of functional groups: the carbonyl group (aldehydes, ketones,
acyl compounds), unsaturated systems (alkenes and aromatic compounds),
substitution reactions (alkyl halides and alcohols).
Part 2: practical session
Advanced exercises on chemical conversion, synthesis and refining the
reaction products.
Teaching Methods
Contacting hours: lectures (illustrated with molecule models) and
theoretical examples (theoretical session); demonstrations and practical
exercises (practical session);
Home study: It's expected that the students perform, on an individual basis,
the additional theoretical exercises, found after each chapter.
Nevertheless, supplementary explanation can be obtained by appointment.
Materials used
Teacher's courses. Additional notes and background information given during
the lectures, also belong to the examination subject.
Textbooks for optional background information:
* "Advanced Organic Chemistry", J. March; Publ.Wiley & Sons, 1992.
* "A Text-Book of Practical Organic Chemistry", A. Vogel; Publ. Longman.
Study guidance
Assessment
Part 1: theoretical session: written examination (open questions on the
theory and the exercices partially taken from the course and from the
additional notes) (67÷);
Part 2: practical session: permanent evaluation and practical tests (33÷).
Study costs
Lecturer(s)
Paul VANHEE
Language
Dutch
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